PDE9A

PDE9A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HD1, 2YY2, 3DY8, 3DYL, 3DYN, 3DYQ, 3DYS, 3JSI, 3JSW, 3K3E, 3K3H, 3N3Z, 3QI3, 3QI4, 4E90, 4G2J, 4G2L, 4GH6, 4Y86, 4Y87, 4Y8C
Identifiers
Aliases	PDE9A, HSPDE9A2, phosphodiesterase 9A
External IDs	OMIM: 602973; MGI: 1277179; HomoloGene: 113565; GeneCards: PDE9A; OMA:PDE9A - orthologs
EC number	3.1.4.35
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,775,509 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,476,310 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; muscle layer of sigmoid colon; ; ganglionic eminence; ; ventricular zone; ; oocyte; ; sural nerve; ; prostate; ; rectum; ; optic nerve; ; secondary oocyte;
	Top expressed in
	colon; ; duodenum; ; left colon; ; jejunum; ; cerebellar vermis; ; ileum; ; lobe of cerebellum; ; crypt of lieberkuhn of small intestine; ; olfactory tubercle; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein binding; phosphoric diester hydrolase activity; hydrolase activity; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytoplasm; cytosol; perikaryon; Golgi apparatus; cell projection; membrane; plasma membrane; ruffle membrane; endoplasmic reticulum; perinuclear region of cytoplasm; sarcolemma;
Biological process	cGMP metabolic process; cGMP-mediated signaling; positive regulation of cardiac muscle hypertrophy; cGMP catabolic process; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5152
	18585
	ENSG00000160191
	ENSMUSG00000041119
	O76083
	O70628
NM_001001567; NM_001001568; NM_001001569; NM_001001570; NM_001001571;
	NM_001001572; NM_001001573; NM_001001574; NM_001001575; NM_001001576; NM_001001577; NM_001001578; NM_001001579; NM_001001580; NM_001001581; NM_001001582; NM_001001583; NM_001001584; NM_001001585; NM_002606; NM_001315533
	NM_001163748; NM_008804
NP_001001567; NP_001001568; NP_001001569; NP_001001570; NP_001001571;
	NP_001001572; NP_001001573; NP_001001574; NP_001001575; NP_001001576; NP_001001577; NP_001001578; NP_001001579; NP_001001580; NP_001001581; NP_001001582; NP_001001583; NP_001001584; NP_001001585; NP_001302462; NP_002597
	NP_001157220; NP_032830
	Wikidata
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an enzyme that in humans is encoded by the PDE9A gene.

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.