PDGFRB

PDGFRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG
Identifiers
Aliases	PDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth factor receptor beta
External IDs	OMIM: 173410; MGI: 97531; HomoloGene: 1960; GeneCards: PDGFRB; OMA:PDGFRB - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,155,872 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,218,133 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right coronary artery; ; canal of the cervix; ; tibial arteries; ; gallbladder; ; Descending thoracic aorta; ; right ovary; ; Achilles tendon; ; right lung; ; left coronary artery;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; tunica media of zone of aorta; ; calvaria; ; epithelium of lens; ; left lung lobe; ; vas deferens; ; body of femur; ; dermis; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vascular endothelial growth factor binding; kinase activity; platelet-derived growth factor-activated receptor activity; transmembrane receptor protein tyrosine kinase activity; signaling receptor binding; ATP binding; protein kinase activity; platelet-derived growth factor binding; platelet activating factor receptor activity; transferase activity; platelet-derived growth factor receptor binding; protein binding; protein tyrosine kinase activity; protein kinase binding; platelet-derived growth factor beta-receptor activity; nucleotide binding; phosphatidylinositol 3-kinase binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; enzyme binding;
Cellular component	cytoplasm; membrane; focal adhesion; nucleus; apical plasma membrane; lysosome; extracellular exosome; integral component of membrane; plasma membrane; lysosomal lumen; intrinsic component of plasma membrane; cytoplasmic vesicle; cell surface; Golgi apparatus; integral component of plasma membrane; intracellular membrane-bounded organelle; receptor complex;
Biological process	positive regulation of MAP kinase activity; positive regulation of phospholipase C activity; cell migration involved in vasculogenesis; cardiac myofibril assembly; positive regulation of smooth muscle cell migration; protein phosphorylation; response to lipid; positive regulation of phosphoprotein phosphatase activity; positive regulation of reactive oxygen species metabolic process; metanephric glomerular mesangial cell proliferation involved in metanephros development; positive regulation of ERK1 and ERK2 cascade; cell chemotaxis; inner ear development; metanephric S-shaped body morphogenesis; positive regulation of mitotic nuclear division; platelet-derived growth factor receptor-beta signaling pathway; positive regulation of collagen biosynthetic process; phosphatidylinositol metabolic process; transmembrane receptor protein tyrosine kinase signaling pathway; cell migration involved in coronary angiogenesis; metanephric comma-shaped body morphogenesis; positive regulation of chemotaxis; positive regulation of DNA biosynthetic process; protein autophosphorylation; platelet-derived growth factor receptor signaling pathway; response to toxic substance; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; regulation of actin cytoskeleton organization; response to retinoic acid; phosphorylation; response to hyperoxia; retina vasculature development in camera-type eye; metanephric glomerulus morphogenesis; metanephric mesenchymal cell migration; wound healing; cellular response to platelet-derived growth factor stimulus; negative regulation of apoptotic process; response to fluid shear stress; response to estrogen; chemotaxis; metanephric mesenchyme development; response to hydrogen peroxide; positive regulation of smooth muscle cell proliferation; response to estradiol; intracellular signal transduction; response to organic cyclic compound; smooth muscle cell chemotaxis; positive regulation of cell migration; aorta morphogenesis; MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; metanephric glomerular capillary formation; multicellular organism development; positive regulation of calcium ion import; glycosaminoglycan biosynthetic process; positive regulation of cell population proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; cell migration; signal transduction; positive regulation of Rho protein signal transduction; G protein-coupled receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; positive regulation of hepatic stellate cell activation; positive regulation of fibroblast proliferation; positive regulation of apoptotic process; ageing; male gonad development; lung growth; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; phosphatidylinositol-mediated signaling; positive regulation of protein kinase B signaling; hematopoietic progenitor cell differentiation; positive regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	5159
	18596
	ENSG00000113721
	ENSMUSG00000024620
	P09619
	P05622
	NM_002609; NM_001355016; NM_001355017
	NM_001146268; NM_008809
	NP_002600; NP_001341945; NP_001341946
	NP_001139740; NP_032835
	Wikidata
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Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.