PDK2

PDK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BTZ, 2BU2, 2BU5, 2BU6, 2BU7, 2BU8, 4MP2, 4MP7, 4MPC, 4MPE, 4MPN, 4V25, 4V26
Identifiers
Aliases	PDK2, PDHK2, PDKII, pyruvate dehydrogenase kinase 2
External IDs	OMIM: 602525; MGI: 1343087; HomoloGene: 68265; GeneCards: PDK2; OMA:PDK2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,112,152 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,932,180 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; right hemisphere of cerebellum; ; apex of heart; ; gastrocnemius muscle; ; right auricle of heart; ; left adrenal cortex; ; left ventricle; ; right adrenal cortex; ; gastric mucosa; ; right frontal lobe;
	Top expressed in
	interventricular septum; ; muscle of thigh; ; skeletal muscle tissue; ; myocardium of ventricle; ; digastric muscle; ; triceps brachii muscle; ; medial head of gastrocnemius muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; extraocular muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein homodimerization activity; kinase activity; ATP binding; pyruvate dehydrogenase (acetyl-transferring) kinase activity;
Cellular component	nucleoplasm; mitochondrial matrix; mitochondrion; mitochondrial pyruvate dehydrogenase complex; cytosol;
Biological process	phosphorylation; cellular response to reactive oxygen species; intrinsic apoptotic signaling pathway by p53 class mediator; glucose metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; cellular response to nutrient; insulin receptor signaling pathway; regulation of cellular ketone metabolic process; regulation of glucose metabolic process; glucose homeostasis; regulation of pH; protein phosphorylation; regulation of gluconeogenesis; carbohydrate metabolic process; regulation of calcium-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	5164
	18604
	ENSG00000005882
	ENSMUSG00000038967
	Q15119
	Q9JK42
	NM_002611; NM_001199898; NM_001199899; NM_001199900
	NM_133667; NM_001361915
	NP_001186827; NP_001186828; NP_001186829; NP_002602
	NP_598428; NP_001348844
	Wikidata
View/Edit Human	View/Edit Mouse

Pyruvate dehydrogenase kinase isoform 2 (PDK2) also known as pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial is an enzyme that in humans is encoded by the PDK2 gene. PDK2 is an isozyme of pyruvate dehydrogenase kinase.