PDLIM3

PDLIM3
Identifiers
Aliases	PDLIM3, ALP, PDZ and LIM domain 3
External IDs	OMIM: 605889; MGI: 1859274; HomoloGene: 8710; GeneCards: PDLIM3; OMA:PDLIM3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	185,535,507 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	46,372,585 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; glutes; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; gastrocnemius muscle; ; body of tongue; ; right coronary artery; ; thoracic diaphragm; ; ascending aorta;
	Top expressed in
	ankle; ; muscle of thigh; ; triceps brachii muscle; ; medial head of gastrocnemius muscle; ; vastus lateralis muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; ascending aorta; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; cytoskeletal protein binding; structural constituent of muscle; actin binding; muscle alpha-actinin binding;
Cellular component	Z discdkac; cytoplasm; actin cytoskeleton; stress fiber; filamentous actin;
Biological process	heart development; actin filament organization; actin cytoskeleton organization; muscle structure development;
	Sources:Amigo / QuickGO
Orthologs
	27295
	53318
	ENSG00000154553
	ENSMUSG00000031636
	Q53GG5
	O70209
	NM_001114107; NM_001257962; NM_001257963; NM_014476
	NM_016798; NM_001374652
	NP_001107579; NP_001244891; NP_001244892; NP_055291
	NP_058078; NP_001361581
	Wikidata
View/Edit Human	View/Edit Mouse

Actin-associated LIM protein (ALP), also known as PDZ and LIM domain protein 3 is a protein that in humans is encoded by the PDLIM3 gene. ALP is highly expressed in cardiac and skeletal muscle, where it localizes to Z-discs and intercalated discs. ALP functions to enhance the crosslinking of actin by alpha-actinin-2 and also appears to be essential for right ventricular chamber formation and contractile function.