Phosphoinositide-dependent kinase-1

PDPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H1W, 1OKY, 1OKZ, 1UU3, 1UU7, 1UU8, 1UU9, 1UVR, 1W1D, 1W1G, 1W1H, 1Z5M, 2BIY, 2PE0, 2PE1, 2PE2, 2R7B, 2VKI, 2XCH, 2XCK, 3H9O, 3HRC, 3HRF, 3ION, 3IOP, 3NAX, 3NAY, 3NUN, 3NUS, 3NUU, 3NUY, 3ORX, 3ORZ, 3OTU, 3PWY, 3QC4, 3QCQ, 3QCS, 3QCX, 3QCY, 3QD0, 3QD3, 3QD4, 3RCJ, 3RWP, 3RWQ, 3SC1, 4A06, 4A07, 4AW0, 4AW1, 4CT1, 4CT2, 4RQV, 4RRV, 4XX9, 5ACK, 5HO7, 5HO8, 5HKM, 5HNG
Identifiers
Aliases	PDPK1, PDK1, PDPK2, PRO0461, PDPK2P, Phosphoinositide-dependent kinase-1, 3-phosphoinositide dependent protein kinase 1
External IDs	OMIM: 605213; MGI: 1338068; HomoloGene: 37643; GeneCards: PDPK1; OMA:PDPK1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,603,188 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,369,898 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; middle temporal gyrus; ; Brodmann area 23; ; bronchial epithelial cell; ; parotid gland; ; caput epididymis; ; corpus epididymis; ; mucosa of sigmoid colon; ; external globus pallidus; ; visceral pleura;
	Top expressed in
	Rostral migratory stream; ; nucleus accumbens; ; seminiferous tubule; ; ventromedial nucleus; ; zygote; ; pontine nuclei; ; olfactory tubercle; ; anterior amygdaloid area; ; facial motor nucleus; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; phospholipase binding; insulin receptor binding; 3-phosphoinositide-dependent protein kinase activity; protein serine/threonine kinase activity; phospholipase activator activity; protein binding; ATP binding; protein kinase binding; kinase activity;
Cellular component	cytoplasm; cytosol; cell projection; membrane; focal adhesion; plasma membrane; nucleoplasm; cell junction; nucleus; perikaryon; postsynaptic density; cytoplasmic vesicle;
Biological process	intracellular signal transduction; regulation of transcription, DNA-templated; extrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; phosphorylation; T cell costimulation; stimulatory C-type lectin receptor signaling pathway; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transforming growth factor beta receptor signaling pathway; hyperosmotic response; transcription, DNA-templated; platelet activation; cellular response to epidermal growth factor stimulus; Fc-epsilon receptor signaling pathway; positive regulation of phospholipase activity; protein phosphorylation; negative regulation of cardiac muscle cell apoptotic process; focal adhesion assembly; negative regulation of toll-like receptor signaling pathway; peptidyl-serine phosphorylation; regulation of endothelial cell migration; cellular response to insulin stimulus; protein autophosphorylation; regulation of mast cell degranulation; peptidyl-threonine phosphorylation; type B pancreatic cell development; T cell receptor signaling pathway; cell migration; actin cytoskeleton organization; regulation of I-kappaB kinase/NF-kappaB signaling; calcium-mediated signaling; negative regulation of neuron apoptotic process; cellular response to brain-derived neurotrophic factor stimulus; epidermal growth factor receptor signaling pathway; positive regulation of protein localization to plasma membrane; activation of protein kinase B activity; positive regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of vascular endothelial cell proliferation; positive regulation of sprouting angiogenesis; negative regulation of endothelial cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5170
	18607
	ENSG00000140992
	ENSMUSG00000024122
	O15530
	Q9Z2A0
	NM_001261816; NM_002613; NM_031268
	NM_001080773; NM_001286662; NM_011062
	NP_001248745; NP_002604; NP_112558
	NP_001074242; NP_001273591; NP_035192
	Wikidata
View/Edit Human	View/Edit Mouse

In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans. It is implicated in the development and progression of melanomas.