PEG3

PEG3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BHX
Identifiers
Aliases	PEG3, PW1, ZKSCAN22, ZNF904, ZSCAN24, paternally expressed 3
External IDs	OMIM: 601483; MGI: 104748; HomoloGene: 31363; GeneCards: PEG3; OMA:PEG3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	56,840,728 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	6,730,431 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; superior vestibular nucleus; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; Pons; ; Epithelium of choroid plexus; ; middle temporal gyrus; ; ventral tegmental area; ; external globus pallidus; ; dorsal motor nucleus of vagus nerve;
	Top expressed in
	umbilical cord; ; condyle; ; medullary collecting duct; ; pituitary gland; ; substantia nigra; ; ventromedial nucleus; ; fossa; ; human fetus; ; dorsomedial hypothalamic nucleus; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; autophagosome;
Biological process	apoptotic process; regulation of gene expression; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5178
	18616
	ENSG00000198300
	ENSMUSG00000002265
	Q9GZU2
	Q3URU2
	NM_006210; NM_001146184; NM_001146185; NM_001146186; NM_001146187
	NM_008817
	NP_001139656; NP_001139657; NP_001139658; NP_001139659; NP_006201
	NP_032843
	Wikidata
View/Edit Human	View/Edit Mouse

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene. PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction. PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.