PERP

PERP
Identifiers
Aliases	PERP, KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1, TP53 apoptosis effector, p53 apoptosis effector related to PMP22, EKVP7, OLMS2
External IDs	OMIM: 609301; MGI: 1929938; HomoloGene: 11098; GeneCards: PERP; OMA:PERP - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	138,107,419 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	18,732,821 bp
RNA expression pattern
	Top expressed in
	human penis; ; skin of thigh; ; mucosa of pharynx; ; nipple; ; skin of hip; ; vulva; ; oral cavity; ; gingival epithelium; ; body of tongue; ; epithelium of nasopharynx;
	Top expressed in
	corneal stroma; ; epidermis; ; hair follicle; ; skin of external ear; ; lip; ; skin of back; ; transitional epithelium of urinary bladder; ; skin of abdomen; ; molar; ; esophagus;
	More reference expression data
	More reference expression data
Orthologs
	64065
	64058
	ENSG00000112378
	ENSMUSG00000019851
	Q96FX8
	Q9JK95
	NM_022121
	NM_022032
	NP_071404
	NP_071315
	Wikidata
View/Edit Human	View/Edit Mouse

p53 apoptosis effector related to PMP-22 is a plasma membrane protein that, in humans, is encoded by the PERP gene.

PERP is a direct transcriptional target of p53, but its transcription can also be regulated by other transcription factors.

PERP is important for skin development, and loss of PERP is associated with the development and progression of several types of human cancers.