PES1

PES1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EP8
Identifiers
Aliases	PES1, PES, pescadillo ribosomal biogenesis factor 1, NOP7
External IDs	OMIM: 605819; MGI: 1890613; HomoloGene: 5984; GeneCards: PES1; OMA:PES1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,607,083 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,930,004 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; body of pancreas; ; islet of Langerhans; ; skin of leg; ; mucosa of transverse colon; ; skin of abdomen; ; left testis; ; stromal cell of endometrium; ; body of stomach; ; right testis;
	Top expressed in
	interventricular septum; ; yolk sac; ; spermatocyte; ; ventricular zone; ; neural layer of retina; ; tail of embryo; ; spermatid; ; otic vesicle; ; embryo; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; ribonucleoprotein complex binding;
Cellular component	membrane; PeBoW complex; chromosome; nucleolus; condensed chromosome; nucleus; nucleoplasm; cytosol; preribosome, large subunit precursor;
Biological process	protein localization to organelle; ribosome biogenesis; regulation of cell cycle; nucleolus organization; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cell population proliferation; rRNA processing; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis;
	Sources:Amigo / QuickGO
Orthologs
	23481
	64934
	ENSG00000100029
	ENSMUSG00000020430
	O00541
	Q9EQ61
	NM_001243225; NM_001282327; NM_001282328; NM_014303
	NM_022889
	NP_001230154; NP_001269256; NP_001269257; NP_055118
	NP_075027
	Wikidata
View/Edit Human	View/Edit Mouse

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.