Peroxisomal biogenesis factor 2

PEX2
Identifiers
Aliases	PEX2, PAF1, PBD5A, PBD5B, PMP3, PMP35, PXMP3, RNF72, ZWS3, peroxisomal biogenesis factor 2
External IDs	OMIM: 170993; MGI: 107486; HomoloGene: 269; GeneCards: PEX2; OMA:PEX2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	77,001,044 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	5,641,299 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; ventricular zone; ; olfactory zone of nasal mucosa; ; islet of Langerhans; ; rectum; ; monocyte; ; epithelium of colon; ; right adrenal cortex; ; gallbladder; ; body of pancreas;
	Top expressed in
	proximal tubule; ; right kidney; ; medullary collecting duct; ; seminal vesicula; ; intercostal muscle; ; epithelium of lens; ; medial ganglionic eminence; ; vestibular sensory epithelium; ; atrioventricular valve; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin protein ligase activity;
Cellular component	Cdc73/Paf1 complex; peroxisome; integral component of peroxisomal membrane; integral component of membrane; membrane; peroxisomal membrane;
Biological process	negative regulation of fibroblast proliferation; protein import into peroxisome matrix; fatty acid beta-oxidation; protein destabilization; very long-chain fatty acid metabolic process; negative regulation of transcription by RNA polymerase II; peroxisome organization; negative regulation of epithelial cell proliferation; protein ubiquitination; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	5828
	19302
	ENSG00000164751
	ENSMUSG00000040374
	P28328
	P55098
	NM_001172087; NM_000318; NM_001079867; NM_001172086
NM_001163301; NM_001163302; NM_001163304; NM_001163305; NM_001163306;
	NM_001267714; NM_001267715; NM_008994
	NP_000309; NP_001073336; NP_001165557; NP_001165558
NP_001156773; NP_001156774; NP_001156777; NP_001156778; NP_001254643;
	NP_001254644; NP_033020
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal biogenesis factor 2 is a protein that in humans is encoded by the PEX2 gene.

This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein.