PFKFB1

PFKFB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K6M
Identifiers
Aliases	PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDs	OMIM: 311790; MGI: 107816; HomoloGene: 105654; GeneCards: PFKFB1; OMA:PFKFB1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	54,998,534 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	149,426,874 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; right lobe of liver; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; gonad; ; vastus lateralis muscle; ; muscle of arm; ; biceps brachii; ; testicle; ; triceps brachii muscle;
	Top expressed in
	muscle of thigh; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; masseter muscle; ; tibialis anterior muscle; ; temporal muscle; ; digastric muscle; ; gastrocnemius muscle; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; fructose-6-phosphate binding; kinase activity; catalytic activity; protein binding; identical protein binding; fructose-2,6-bisphosphate 2-phosphatase activity; hydrolase activity; ATP binding; 6-phosphofructo-2-kinase activity; kinase binding;
Cellular component	cytosol; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;
Biological process	gluconeogenesis; response to glucagon; glycolytic process; phosphorylation; fructose metabolic process; response to glucocorticoid; carbohydrate phosphorylation; response to insulin; positive regulation of glucokinase activity; fructose 2,6-bisphosphate metabolic process; animal organ regeneration; response to starvation; metabolism; response to cAMP; dephosphorylation; negative regulation of glycolytic process; positive regulation of glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	5207
	18639
	ENSG00000158571
	ENSMUSG00000025271
	P16118
	P70266
	NM_001271804; NM_001271805; NM_002625
NM_008824; NM_001374170; NM_001374171; NM_001374172; NM_001374173;
	NM_001374175
	NP_001258733; NP_001258734; NP_002616
NP_032850; NP_001361099; NP_001361100; NP_001361101; NP_001361102;
	NP_001361104
	Wikidata
View/Edit Human	View/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.