PFKFB2

PFKFB2
Identifiers
Aliases	PFKFB2, PFK-2/FBPase-2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
External IDs	OMIM: 171835; MGI: 107815; HomoloGene: 88554; GeneCards: PFKFB2; OMA:PFKFB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	207,081,024 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,656,990 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; oocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastrocnemius muscle; ; rectum; ; apex of heart; ; duodenum; ; anterior pituitary; ; left ventricle;
	Top expressed in
	neural layer of retina; ; spermatocyte; ; islet of Langerhans; ; spermatid; ; superior frontal gyrus; ; pineal gland; ; lumbar subsegment of spinal cord; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; protein binding; catalytic activity; fructose-2,6-bisphosphate 2-phosphatase activity; hydrolase activity; ATP binding; protein kinase binding; 6-phosphofructo-2-kinase activity; kinase binding;
Cellular component	cytoplasm; cytosol; nucleus; nucleoplasm;
Biological process	lactate metabolic process; glycolytic process; phosphorylation; fructose metabolic process; response to glucose; positive regulation of glucokinase activity; fructose 2,6-bisphosphate metabolic process; pyruvate metabolic process; glucose catabolic process; metabolism; positive regulation of insulin secretion; dephosphorylation; carbohydrate phosphorylation; positive regulation of glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	5208
	18640
	ENSG00000123836
	ENSMUSG00000026409
	O60825
	P70265
	NM_001018053; NM_006212
	NM_001162415; NM_001162416; NM_008825; NM_001368843
	NP_001018063; NP_006203
	NP_001155887; NP_001155888; NP_032851; NP_001355772
	Wikidata
View/Edit Human	View/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.