PFKL

PFKL
Identifiers
Aliases	PFKL, ATP-PFK, PFK-B, PFK-L, phosphofructokinase, liver type
External IDs	OMIM: 171860; MGI: 97547; HomoloGene: 55668; GeneCards: PFKL; OMA:PFKL - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	44,327,376 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,845,917 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; tibial nerve; ; C1 segment; ; right frontal lobe; ; skin of abdomen; ; body of stomach; ; skin of leg; ; canal of the cervix; ; right uterine tube; ; ectocervix;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; vestibular membrane of cochlear duct; ; perirhinal cortex; ; otic vesicle; ; brown adipose tissue; ; primitive streak; ; CA3 field; ; entorhinal cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; monosaccharide binding; metal ion binding; kinase activity; fructose binding; kinase binding; protein binding; catalytic activity; identical protein binding; ATP binding; 6-phosphofructokinase activity; fructose-6-phosphate binding; AMP binding;
Cellular component	cytoplasm; membrane; 6-phosphofructokinase complex; extracellular exosome; cytosol; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	negative regulation of insulin secretion; phosphorylation; canonical glycolysis; protein complex oligomerization; metabolism; glycolytic process through fructose-6-phosphate; protein homotetramerization; glycolytic process; fructose 6-phosphate metabolic process; fructose 1,6-bisphosphate metabolic process; response to glucose; neutrophil degranulation; carbohydrate metabolic process; glucose catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5211
	18641
	ENSG00000141959
	ENSMUSG00000020277
	P17858; Q7L2M7
	P12382
	NM_001002021; NM_002626
	NM_008826; NM_001358793
	NP_001002021; NP_002617; NP_001002021.2; NP_002617.3
	NP_032852; NP_001345722
	Wikidata
View/Edit Human	View/Edit Mouse

6-phosphofructokinase, liver type (PFKL) is an enzyme that in humans is encoded by the PFKL gene on chromosome 21. This gene encodes the liver (L) isoform of phosphofructokinase-1, an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]