Profilin 1

PFN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AWI, 1CF0, 1CJF, 1FIK, 1FIL, 1PFL, 2PAV, 2PBD, 3CHW, 4X1L, 4X1M, 4X25
Identifiers
Aliases	PFN1, ALS18, Profilin 1
External IDs	OMIM: 176610; MGI: 97549; HomoloGene: 3684; GeneCards: PFN1; OMA:PFN1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,949,061 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,545,470 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; muscle layer of sigmoid colon; ; mucosa of ileum; ; monocyte; ; thoracic aorta; ; ascending aorta; ; stromal cell of endometrium; ; Descending thoracic aorta; ; left coronary artery;
	Top expressed in
	granulocyte; ; yolk sac; ; tail of embryo; ; thymus; ; tibiofemoral joint; ; lymph node; ; mesenteric lymph nodes; ; genital tubercle; ; epiblast; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin monomer binding; protein binding; adenyl-nucleotide exchange factor activity; actin binding; proline-rich region binding; RNA binding; cadherin binding; signaling receptor binding; phosphatidylinositol-4,5-bisphosphate binding;
Cellular component	cytosol; blood microparticle; membrane; focal adhesion; cell cortex; extracellular exosome; cytoskeleton; cytoplasm; nucleus; extracellular space; neuron projection; synapse; glutamatergic synapse;
Biological process	positive regulation of actin filament polymerization; positive regulation of ATP-dependent activity; negative regulation of actin filament polymerization; positive regulation of ruffle assembly; regulation of transcription by RNA polymerase II; protein stabilization; positive regulation of epithelial cell migration; negative regulation of actin filament bundle assembly; neural tube closure; positive regulation of actin filament bundle assembly; negative regulation of stress fiber assembly; actin cytoskeleton organization; Wnt signaling pathway, planar cell polarity pathway; response to organic substance; positive regulation of transcription by RNA polymerase II; positive regulation of viral transcription; positive regulation of DNA metabolic process; positive regulation of stress fiber assembly; cellular response to growth factor stimulus; regulation of actin filament polymerization; synapse maturation; modification of postsynaptic actin cytoskeleton;
	Sources:Amigo / QuickGO
Orthologs
	5216
	18643
	ENSG00000108518
	ENSMUSG00000018293
	P07737
	P62962
	NM_005022; NM_001375991
	NM_011072
	NP_005013; NP_001362920
	NP_035202
	Wikidata
View/Edit Human	View/Edit Mouse

Profilin-1 is a protein that in humans is encoded by the PFN1 gene.