PFN2

PFN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D1J
Identifiers
Aliases	PFN2, D3S1319E, PFL, profilin 2
External IDs	OMIM: 176590; MGI: 97550; HomoloGene: 1974; GeneCards: PFN2; OMA:PFN2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	150,050,788 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; superior frontal gyrus; ; postcentral gyrus; ; Brodmann area 10; ; Pons; ; middle temporal gyrus; ; orbitofrontal cortex; ; ganglionic eminence; ; glutes; ; ventricular zone;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; phosphatidylinositol-4,5-bisphosphate binding; actin monomer binding; protein binding; ATPase activity;
Cellular component	cytoplasm; terminal bouton; extracellular exosome; cytoskeleton; Schaffer collateral - CA1 synapse; presynapse; postsynapse; glutamatergic synapse;
Biological process	regulation of actin filament polymerization; regulation of synaptic vesicle exocytosis; protein stabilization; positive regulation of actin filament bundle assembly; positive regulation of actin filament polymerization; negative regulation of actin filament polymerization; positive regulation of ATP-dependent activity; negative regulation of epithelial cell migration; positive regulation of stress fiber assembly; actin cytoskeleton organization; positive regulation of peptidyl-serine phosphorylation; negative regulation of ruffle assembly; modification of postsynaptic actin cytoskeleton;
	Sources:Amigo / QuickGO
Orthologs
	5217
	18645
	ENSG00000070087
	ENSMUSG00000027805
	P35080
	Q9JJV2
	NM_053024; NM_002628
	NM_019410
	NP_002619; NP_444252
	NP_062283
	Wikidata
View/Edit Human	View/Edit Mouse

Profilin-2 is a protein that in humans is encoded by the PFN2 gene.

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.