Peptidoglycan recognition protein 1

PGLYRP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YCK
Identifiers
Aliases	PGLYRP1, PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L, peptidoglycan recognition protein 1
External IDs	OMIM: 604963; MGI: 1345092; HomoloGene: 74539; GeneCards: PGLYRP1; OMA:PGLYRP1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	46,023,053 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	18,624,384 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; trabecular bone; ; blood; ; granulocyte; ; spleen; ; monocyte; ; right lung; ; upper lobe of left lung; ; right lobe of liver;
	Top expressed in
	granulocyte; ; crypt of lieberkuhn of small intestine; ; tibiofemoral joint; ; corneal stroma; ; left colon; ; submandibular gland; ; conjunctival fornix; ; duodenum; ; ileum; ; trachea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; peptidoglycan immune receptor activity; N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan binding;
Cellular component	extracellular exosome; extracellular region; specific granule lumen; phagocytic vesicle lumen; tertiary granule lumen; extracellular space;
Biological process	peptidoglycan catabolic process; negative regulation of natural killer cell differentiation involved in immune response; negative regulation of interferon-gamma production; innate immune response; negative regulation of inflammatory response; defense response to bacterium; immune response; detection of bacterium; immune system process; defense response to Gram-positive bacterium; pattern recognition receptor signaling pathway; antimicrobial humoral response; neutrophil degranulation; positive regulation of cytolysis in other organism; antimicrobial humoral immune response mediated by antimicrobial peptide; response to bacterium; killing of cells of other organism;
	Sources:Amigo / QuickGO
Orthologs
	8993
	21946
	ENSG00000008438
	ENSMUSG00000030413
	O75594
	O88593
	NM_005091
	NM_009402
	NP_005082
	NP_033428
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidoglycan recognition protein 1, PGLYRP1, also known as TAG7, is an antibacterial and pro-inflammatory innate immunity protein that in humans is encoded by the PGLYRP1 gene.