Peptidoglycan recognition protein 3

PGLYRP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SK3, 1SK4, 1TWQ, 2APH
Identifiers
Aliases	PGLYRP3, PGRP-Ialpha, PGRPIA, PGLYRPIalpha, peptidoglycan recognition protein 3
External IDs	OMIM: 608197; MGI: 2685266; HomoloGene: 71559; GeneCards: PGLYRP3; OMA:PGLYRP3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,312,952 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	91,938,889 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; vagina; ; tonsil; ; ectocervix; ; gonad; ; minor salivary glands; ; right lung; ; upper respiratory tract; ; face;
	Top expressed in
	esophagus; ; lip; ; embryo; ; zone of skin; ; tail of embryo; ; spinal ganglia; ; peripheral nervous system; ; foregut; ; stomach; ; limb;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan immune receptor activity; peptidoglycan binding; protein heterodimerization activity;
Cellular component	intracellular anatomical structure; membrane; extracellular region; protein-containing complex; extracellular space;
Biological process	immune system process; negative regulation of natural killer cell differentiation involved in immune response; negative regulation of interferon-gamma production; innate immune response; defense response to bacterium; detection of bacterium; defense response to Gram-positive bacterium; peptidoglycan catabolic process; pattern recognition receptor signaling pathway; antimicrobial humoral response; positive regulation of cytolysis in other organism; antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism;
	Sources:Amigo / QuickGO
Orthologs
	114771
	242100
	ENSG00000159527
	ENSMUSG00000042244
	Q96LB9
	A1A547
	NM_052891
	NM_207247
	NP_443123
	NP_997130
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidoglycan recognition protein 3 (PGLYRP3, formerly PGRP-Iα) is an antibacterial and anti-inflammatory innate immunity protein that in humans is encoded by the PGLYRP3 gene.