Phosphatase and actin regulator 1

PHACTR1
Identifiers
Aliases	PHACTR1, RPEL, RPEL1, dJ257A7.2, phosphatase and actin regulator 1, EIEE70, DEE70
External IDs	OMIM: 608723; MGI: 2659021; HomoloGene: 33597; GeneCards: PHACTR1; OMA:PHACTR1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	13,290,446 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	43,292,002 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; nucleus accumbens; ; ganglionic eminence; ; prefrontal cortex; ; superior frontal gyrus; ; right frontal lobe; ; caudate nucleus; ; dorsolateral prefrontal cortex; ; entorhinal cortex; ; putamen;
	Top expressed in
	nucleus accumbens; ; dorsal striatum; ; superior frontal gyrus; ; olfactory tubercle; ; visual cortex; ; primary visual cortex; ; lateral septal nucleus; ; Rostral migratory stream; ; prefrontal cortex; ; temporal lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein phosphatase inhibitor activity; protein phosphatase 1 binding; actin binding; protein phosphatase regulator activity;
Cellular component	cytoplasm; cytosol; cell junction; synapse; nucleus;
Biological process	actin cytoskeleton reorganization; actomyosin structure organization; stress fiber assembly; cell motility; negative regulation of phosphoprotein phosphatase activity; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	221692
	218194
	ENSG00000112137
	ENSMUSG00000054728
	Q9C0D0
	Q2M3X8
NM_001242648; NM_030948; NM_001322308; NM_001322309; NM_001322310;
	NM_001322311; NM_001322312; NM_001322313; NM_001322314; NM_001374581; NM_001374582; NM_001374583; NM_001374584
	NM_001005740; NM_001005748; NM_198419; NM_001302635; NM_001302636
NP_001229577; NP_001309237; NP_001309238; NP_001309239; NP_001309240;
	NP_001309241; NP_001309242; NP_001309243; NP_112210; NP_001361510; NP_001361511; NP_001361512; NP_001361513
	NP_001005740; NP_001005748; NP_001289564; NP_001289565
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatase and actin regulator 1 (PHACTR1) is a protein that in humans is encoded by the PHACTR1 gene on chromosome 6. It is most significantly expressed in the globus pallidus of the brain. PHACTR1 is an actin and protein phosphatase 1 (PP1) binding protein that binds actin and regulates the reorganization of the actin cytoskeleton. This protein has been associated with coronary artery disease and migraines through genome-wide association studies. The PHACTR1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.