Phosphoglycerate dehydrogenase

Phosphoglycerate dehydrogenase (PHGDH) is an enzyme that catalyzes the chemical reactions

3-phospho-D-glycerate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 3-phosphonooxypyruvate + NADH + H⁺

2-hydroxyglutarate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 2-oxoglutarate + NADH + H⁺

The two substrates of this enzyme are 3-phospho-D-glycerate and NAD⁺, whereas its 3 products are 3-phosphohydroxypyruvate, NADH, and H⁺

It is also possible that two substrates of this enzyme are 2-hydroxyglutarate and NAD⁺, whereas its 3 products are 2-oxoglutarate, NADH, and H⁺.

As of 2012, the most widely studied variants of PHGDH are from the E. coli and M. tuberculosis genomes. In humans, this enzyme is encoded by the PHGDH gene.