PHLDA2

PHLDA2
Identifiers
Aliases	PHLDA2, BRW1C, BWR1C, HLDA2, IPL, TSSC3, pleckstrin homology like domain family A member 2
External IDs	OMIM: 602131; MGI: 1202307; HomoloGene: 2482; GeneCards: PHLDA2; OMA:PHLDA2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	2,929,420 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	143,056,887 bp
RNA expression pattern
	Top expressed in
	placenta; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; stromal cell of endometrium; ; skin of abdomen; ; vagina; ; ascending aorta; ; gonad; ; prostate; ; testicle;
	Top expressed in
	yolk sac; ; primitive streak; ; embryo; ; epiblast; ; right kidney; ; proximal tubule; ; embryo; ; placenta; ; zygote; ; mesoderm;
	More reference expression data
	More reference expression data
Orthologs
	7262
	22113
	ENSG00000181649; ENSG00000274538
	ENSMUSG00000010760
	Q53GA4
	O08969
	NM_003311
	NM_009434
	NP_003302
	NP_033460
	Wikidata
View/Edit Human	View/Edit Mouse

Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene.

This gene is one of several genes in the imprinted gene domain of 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.