PHOX2B

PHOX2B
Identifiers
Aliases	PHOX2B, NBLST2, NBPhox, PMX2B, paired like homeobox 2b, CCHS
External IDs	OMIM: 603851; MGI: 1100882; HomoloGene: 68371; GeneCards: PHOX2B; OMA:PHOX2B - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	41,748,725 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	67,256,644 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; buccal mucosa cell; ; dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; rectum; ; transverse colon; ; appendix; ; small intestine; ; right adrenal gland; ; duodenum;
	Top expressed in
	migratory enteric neural crest cell; ; external carotid artery; ; pelvic ganglion; ; enteric nervous system; ; internal carotid artery; ; adrenal gland; ; facial motor nucleus; ; female urethra; ; medial vestibular nucleus; ; male urethra;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	negative regulation of cell population proliferation; glial cell differentiation; respiratory system development; positive regulation of G2/M transition of mitotic cell cycle; medullary reticular formation development; transcription, DNA-templated; parasympathetic nervous system development; regulation of respiratory gaseous exchange by nervous system process; noradrenergic neuron development; cellular response to BMP stimulus; multicellular organism development; neural crest cell migration involved in autonomic nervous system development; hindbrain tangential cell migration; sympathetic nervous system development; skeletal muscle cell differentiation; enteric nervous system development; retrotrapezoid nucleus neuron differentiation; regulation of gene expression; positive regulation of neuron differentiation; brainstem development; inner ear development; cell development; regulation of transcription, DNA-templated; sympathetic ganglion development; negative regulation of neuron differentiation; cell differentiation in hindbrain; autonomic nervous system development; efferent axon development in a lateral line nerve; neuron differentiation; neuron migration; dopaminergic neuron differentiation; noradrenergic neuron differentiation; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; positive regulation of cold-induced thermogenesis; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	8929
	18935
	ENSG00000109132
	ENSMUSG00000012520
	Q99453
	O35690
	NM_003924
	NM_008888
	NP_003915
	NP_032914
	Wikidata
View/Edit Human	View/Edit Mouse

Paired-like homeobox 2b (PHOX2B), also known as neuroblastoma Phox (NBPhox), is a protein that in humans is encoded by the PHOX2B gene located on chromosome 4.

It codes for a homeodomain transcription factor. It is expressed exclusively in the nervous system, in most neurons that control the viscera (cardiovascular, digestive and respiratory systems). It is also required for their differentiation.