PIAS1

PIAS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V66
Identifiers
Aliases	PIAS1, DDXBP1, GBP, GU/RH-II, ZMIZ3, protein inhibitor of activated STAT 1
External IDs	OMIM: 603566; MGI: 1913125; HomoloGene: 22953; GeneCards: PIAS1; OMA:PIAS1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	68,198,603 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	62,895,206 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; seminal vesicula; ; nipple; ; caput epididymis; ; tail of epididymis; ; bone marrow cells; ; cardia; ; trabecular bone; ; Achilles tendon; ; buccal mucosa cell;
	Top expressed in
	zygote; ; spermatid; ; secondary oocyte; ; primary oocyte; ; seminiferous tubule; ; pineal gland; ; genital tubercle; ; spermatocyte; ; olfactory tubercle; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; transcription coactivator activity; zinc ion binding; transcription factor binding; metal ion binding; SUMO ligase activity; protein binding; androgen receptor binding; enzyme binding; ubiquitin protein ligase binding; protein domain specific binding; SUMO transferase activity; transferase activity; protein C-terminus binding;
Cellular component	PML body; nuclear speck; nucleoplasm; nucleus;
Biological process	androgen receptor signaling pathway; receptor signaling pathway via JAK-STAT; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; protein sumoylation; transcription, DNA-templated; regulation of interferon-gamma-mediated signaling pathway; regulation of cell population proliferation; fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; visual learning; negative regulation of apoptotic process; positive regulation of smooth muscle cell differentiation; spermatogenesis; positive regulation of protein sumoylation; protein-DNA complex assembly; positive regulation of transcription, DNA-templated; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	8554
	56469
	ENSG00000033800
	ENSMUSG00000032405
	O75925
	O88907
	NM_016166; NM_001320687
	NM_019663
	NP_001307616; NP_057250
	NP_062637
	Wikidata
View/Edit Human	View/Edit Mouse

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.