PIAS4

PIAS4
Identifiers
Aliases	PIAS4, PIASY, Piasg, ZMIZ6, PIAS-gamma, protein inhibitor of activated STAT 4
External IDs	OMIM: 605989; MGI: 2136940; HomoloGene: 104136; GeneCards: PIAS4; OMA:PIAS4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,039,386 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,003,757 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right hemisphere of cerebellum; ; stromal cell of endometrium; ; oocyte; ; sural nerve; ; islet of Langerhans; ; muscle of thigh; ; muscle layer of sigmoid colon; ; monocyte;
	Top expressed in
	seminiferous tubule; ; internal carotid artery; ; spermatid; ; external carotid artery; ; tibiofemoral joint; ; primary oocyte; ; crypt of lieberkuhn of small intestine; ; secondary oocyte; ; granulocyte; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; zinc ion binding; metal ion binding; SUMO ligase activity; protein binding; ubiquitin protein ligase binding; SUMO transferase activity; transferase activity; protein C-terminus binding;
Cellular component	cytoplasm; PML body; nuclear matrix; transferase complex; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; positive regulation of keratinocyte apoptotic process; negative regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; positive regulation of protein sumoylation; protein sumoylation; transcription, DNA-templated; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription, DNA-templated; double-strand break repair via nonhomologous end joining; negative regulation of NF-kappaB transcription factor activity; vitamin D metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51588
	59004
	ENSG00000105229
	ENSMUSG00000004934
	Q8N2W9
	Q9JM05
	NM_015897; NM_016149
	NM_021501
	NP_056981
	NP_067476
	Wikidata
View/Edit Human	View/Edit Mouse

E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as a protein inhibitor of activated STAT protein gamma (PIASg or PIASy), and is an enzyme that in humans is encoded by the PIAS4 gene.