PIGH

PIGH
Identifiers
Aliases	PIGH, GPI-H, phosphatidylinositol glycan anchor biosynthesis class H
External IDs	OMIM: 600154; MGI: 99463; HomoloGene: 3361; GeneCards: PIGH; OMA:PIGH - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,600,286 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	79,136,425 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; left lobe of thyroid gland; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; right lobe of thyroid gland; ; left ovary; ; minor salivary glands; ; right ovary;
	Top expressed in
	Paneth cell; ; transitional epithelium of urinary bladder; ; seminal vesicula; ; conjunctival fornix; ; condyle; ; epithelium of lens; ; fossa; ; renal corpuscle; ; medullary collecting duct; ; lobe of prostate;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; phosphatidylinositol N-acetylglucosaminyltransferase activity; catalytic activity; glycosyltransferase activity;
Cellular component	cytoplasm; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; endoplasmic reticulum; membrane; integral component of membrane;
Biological process	GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	5283
	110417
	ENSG00000100564
	ENSMUSG00000021120
	Q14442
	Q5M9N4
	NM_004569; NM_001363694
	NM_029988
	NP_004560; NP_001350623
	NP_084264
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.