PIGK

PIGK
Identifiers
Aliases	PIGK, GPI8, phosphatidylinositol glycan anchor biosynthesis class K, NEDHCAS
External IDs	OMIM: 605087; MGI: 1913863; HomoloGene: 4002; GeneCards: PIGK; OMA:PIGK - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	77,219,430 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	152,980,408 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Achilles tendon; ; stromal cell of endometrium; ; islet of Langerhans; ; retinal pigment epithelium; ; right coronary artery; ; right ventricle; ; kidney tubule; ; glomerulus; ; popliteal artery;
	Top expressed in
	spermatocyte; ; spermatid; ; cingulate gyrus; ; Ileal epithelium; ; extensor digitorum longus muscle; ; cardiac muscle tissue of left ventricle; ; plantaris muscle; ; supraoptic nucleus; ; calvaria; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GPI-anchor transamidase activity; peptidase activity; cysteine-type peptidase activity; GPI anchor binding; protein binding; hydrolase activity; protein disulfide isomerase activity;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; membrane; GPI-anchor transamidase complex; endoplasmic reticulum;
Biological process	GPI anchor biosynthetic process; attachment of GPI anchor to protein; protein localization to cell surface; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	10026
	329777
	ENSG00000142892
	ENSMUSG00000039047
	Q92643
	Q9CXY9
	NM_005482
	NM_025662; NM_178016
	NP_005473
	NP_079938; NP_821135
	Wikidata
View/Edit Human	View/Edit Mouse

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.

This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.