PIGP

PIGP
Identifiers
Aliases	PIGP, DCRC, DCRC-S, DSCR5, DSRC, PIG-P, phosphatidylinositol glycan anchor biosynthesis class P, EIEE55
External IDs	OMIM: 605938; MGI: 1860433; HomoloGene: 32444; GeneCards: PIGP; OMA:PIGP - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	37,073,170 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	94,172,701 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; Skeletal muscle tissue of biceps brachii; ; tail of epididymis; ; thoracic diaphragm; ; myocardium; ; retinal pigment epithelium; ; vastus lateralis muscle; ; caput epididymis; ; bronchial epithelial cell; ; myocardium of left ventricle;
	Top expressed in
	quadriceps femoris muscle; ; muscle tissue; ; muscle of thigh; ; skeletal muscle tissue; ; zone of skin; ; esophagus; ; heart; ; lens; ; pancreas; ; Mesencephalon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; phosphatidylinositol N-acetylglucosaminyltransferase activity; glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; membrane;
Biological process	preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	51227
	56176
	ENSG00000185808
	ENSMUSG00000022940
	P57054
	Q9JHG1
	NM_153681; NM_153682; NM_001320480; NM_016430
NM_001159616; NM_001159617; NM_001159618; NM_001159619; NM_001159620;
	NM_019543
	NP_001307409; NP_057514; NP_710148; NP_710149
NP_001153088; NP_001153089; NP_001153090; NP_001153091; NP_001153092;
	NP_062416
	Wikidata
View/Edit Human	View/Edit Mouse

Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme subunit that in humans is encoded by the PIGP gene.

This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.