PIGS (gene)

PIGS
Identifiers
Aliases	PIGS, phosphatidylinositol glycan anchor biosynthesis class S, GPIBD18, DEE95
External IDs	OMIM: 610271; MGI: 2687325; HomoloGene: 41963; GeneCards: PIGS; OMA:PIGS - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,571,794 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,233,608 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; granulocyte; ; islet of Langerhans; ; mucosa of transverse colon; ; rectum; ; duodenum; ; monocyte; ; left ventricle; ; right hemisphere of cerebellum; ; blood;
	Top expressed in
	choroid plexus of fourth ventricle; ; spermatocyte; ; entorhinal cortex; ; perirhinal cortex; ; stroma of bone marrow; ; lens; ; muscle of thigh; ; granulocyte; ; lactiferous gland; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; GPI-anchor transamidase activity;
Cellular component	integral component of membrane; GPI-anchor transamidase complex; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	attachment of GPI anchor to protein; GPI anchor biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	94005
	276846
	ENSG00000087111
	ENSMUSG00000041958
	Q96S52
	Q6PD26
	NM_033198
	NM_201406
	NP_149975
	NP_958808
	Wikidata
View/Edit Human	View/Edit Mouse

GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene. This gene encodes a protein that is involved in GPI-anchor biosynthesis.

The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.