PIGT

PIGT
Identifiers
Aliases	PIGT, MCAHS3, NDAP, PNH2, CGI-06, phosphatidylinositol glycan anchor biosynthesis class T
External IDs	OMIM: 610272; MGI: 1926178; HomoloGene: 6134; GeneCards: PIGT; OMA:PIGT - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,456,934 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,350,221 bp
RNA expression pattern
	Top expressed in
	cardia; ; stromal cell of endometrium; ; pylorus; ; right coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; right auricle of heart; ; left coronary artery; ; apex of heart; ; islet of Langerhans;
	Top expressed in
	tail of embryo; ; lip; ; neural layer of retina; ; genital tubercle; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; ventricular zone; ; primary visual cortex; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GPI-anchor transamidase activity;
Cellular component	integral component of membrane; GPI-anchor transamidase complex; endoplasmic reticulum membrane; integral component of endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cytoplasm; cytoplasmic vesicle;
Biological process	attachment of GPI anchor to protein; neuron differentiation; GPI anchor biosynthetic process; neuron apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	51604
	78928
	ENSG00000124155
	ENSMUSG00000017721
	Q969N2
	Q8BXQ2
	NM_001184728; NM_001184729; NM_001184730; NM_015937
	NM_133779; NM_001362644; NM_001362645; NM_001378795
	NP_001171657; NP_001171658; NP_001171659; NP_057021
	NP_598540; NP_001349573; NP_001349574; NP_001365724; NP_001394210
	Wikidata
View/Edit Human	View/Edit Mouse

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.