PIGU

PIGU
Identifiers
Aliases	PIGU, CDC91L1, GAB1, phosphatidylinositol glycan anchor biosynthesis class U, GPIBD21, NEDBSS
External IDs	OMIM: 608528; MGI: 3039607; HomoloGene: 6553; GeneCards: PIGU; OMA:PIGU - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	34,698,790 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,199,350 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; ganglionic eminence; ; ventricular zone; ; islet of Langerhans; ; C1 segment; ; oocyte; ; tibialis anterior muscle; ; gonad; ; rectum; ; right uterine tube;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; genital tubercle; ; tail of embryo; ; muscle of thigh; ; yolk sac; ; right kidney; ; proximal tubule; ; conjunctival fornix; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	GPI-anchor transamidase activity; GPI anchor binding;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; plasma membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; GPI-anchor transamidase complex;
Biological process	GPI anchor biosynthetic process; regulation of receptor signaling pathway via JAK-STAT; attachment of GPI anchor to protein; protein localization to cell surface;
	Sources:Amigo / QuickGO
Orthologs
	128869
	228812
	ENSG00000101464
	ENSMUSG00000038383
	Q9H490
	Q3TAA8
	NM_080476
	NM_001004721
	NP_536724
	NP_001004721
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.