PIK3C2A

PIK3C2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AR5, 2IWL, 2REA, 2RED
Identifiers
Aliases	PIK3C2A, CPK, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha, OCSKD
External IDs	OMIM: 603601; MGI: 1203729; HomoloGene: 20581; GeneCards: PIK3C2A; OMA:PIK3C2A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	17,207,986 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	116,042,684 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; superficial temporal artery; ; retinal pigment epithelium; ; caput epididymis; ; visceral pleura; ; corpus epididymis; ; lower lobe of lung; ; tail of epididymis; ; Epithelium of choroid plexus;
	Top expressed in
	endothelial cell of lymphatic vessel; ; epithelium of lens; ; vestibular sensory epithelium; ; medullary collecting duct; ; seminal vesicula; ; Epithelium of choroid plexus; ; iris; ; tail of embryo; ; vas deferens; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; kinase activity; phosphatidylinositol binding; phosphatidylinositol 3-kinase activity; ATP binding;
Cellular component	cytoplasm; vesicle; cytosol; phosphatidylinositol 3-kinase complex; Golgi apparatus; membrane; plasma membrane; extracellular exosome; cytoplasmic vesicle; clathrin-coated vesicle; nucleus;
Biological process	insulin receptor signaling pathway; endocytosis; epidermal growth factor receptor signaling pathway; phosphorylation; phosphatidylinositol phosphate biosynthetic process; clathrin coat assembly; phosphatidylinositol biosynthetic process; platelet-derived growth factor receptor signaling pathway; phosphatidylinositol-mediated signaling; vascular associated smooth muscle contraction; exocytosis; phosphatidylinositol-3-phosphate biosynthetic process; membrane organization; phosphatidylinositol 3-kinase signaling; cell migration; positive regulation of cell migration involved in sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5286
	18704
	ENSG00000011405
	ENSMUSG00000030660
	O00443
	Q61194
	NM_002645; NM_001321378; NM_001321380; NM_001386870
	NM_011083
	NP_001308307; NP_001308309; NP_002636
	NP_035213
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the PIK3C2A gene.

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking.

This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of Class II PI 3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.