PIK3IP1

PIK3IP1
Identifiers
Aliases	PIK3IP1, HGFL, hHGFL(S), phosphoinositide-3-kinase interacting protein 1, TrIP
External IDs	MGI: 1917016; HomoloGene: 14166; GeneCards: PIK3IP1; OMA:PIK3IP1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,292,534 bp
RNA expression pattern
	Top expressed in
	lymph node; ; olfactory zone of nasal mucosa; ; right lung; ; granulocyte; ; blood; ; gastric mucosa; ; spleen; ; tibial nerve; ; skin of leg; ; skin of abdomen;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol 3-kinase catalytic subunit binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of phosphatidylinositol 3-kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	113791
	216505
	ENSG00000100100
	n/a
	Q96FE7
	Q7TMJ8
	NM_052880; NM_001135911
	NM_178149
	NP_001129383; NP_443112
	NP_835362
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.

PIK3IP1 is a transmembrane protein that binds to PI3K, reducing signal to the PI3K/AKT/mTOR pathway. Through this mechanism, PIK3IP1 inhibits cell proliferation in tumor cells and is associated with cancer. PIK3IP1 is also associated with the inflammatory response and autoimmune diseases.