PIK3R1

PIK3R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4WAF, 5AUL
Identifiers
Aliases	PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1, PI3KR1
External IDs	OMIM: 171833; MGI: 97583; HomoloGene: 7889; GeneCards: PIK3R1; OMA:PIK3R1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	68,301,821 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	101,904,725 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; caput epididymis; ; corpus epididymis; ; postcentral gyrus; ; lactiferous duct; ; tail of epididymis; ; trigeminal ganglion; ; middle temporal gyrus; ; superior frontal gyrus; ; external globus pallidus;
	Top expressed in
	lacrimal gland; ; molar; ; parotid gland; ; intercostal muscle; ; Rostral migratory stream; ; stroma of bone marrow; ; cumulus cell; ; genital tubercle; ; aortic valve; ; skin of external ear;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ErbB-3 class receptor binding; phosphatidylinositol 3-kinase regulator activity; insulin-like growth factor receptor binding; transmembrane receptor protein tyrosine kinase adaptor activity; insulin receptor binding; neurotrophin TRKA receptor binding; phosphatidylinositol 3-kinase regulatory subunit binding; transcription factor binding; insulin binding; phosphatidylinositol 3-kinase binding; 1-phosphatidylinositol-3-kinase regulator activity; protein binding; protein heterodimerization activity; insulin receptor substrate binding; protein phosphatase binding; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotyrosine residue binding;
Cellular component	cytoplasm; cytosol; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA; membrane; cell-cell junction; cis-Golgi network; plasma membrane; nucleus; perinuclear endoplasmic reticulum membrane; protein-containing complex;
Biological process	positive regulation of glucose import; insulin-like growth factor receptor signaling pathway; negative regulation of cell adhesion; positive regulation of endoplasmic reticulum unfolded protein response; epidermal growth factor receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of osteoclast differentiation; positive regulation of cell migration; cellular glucose homeostasis; cellular response to UV; T cell costimulation; protein stabilization; negative regulation of apoptotic process; response to endoplasmic reticulum stress; regulation of stress fiber assembly; negative regulation of cell-matrix adhesion; platelet activation; Fc-epsilon receptor signaling pathway; protein phosphorylation; phosphatidylinositol phosphate biosynthetic process; vascular endothelial growth factor receptor signaling pathway; growth hormone receptor signaling pathway; regulation of phosphatidylinositol 3-kinase activity; intrinsic apoptotic signaling pathway in response to DNA damage; cellular response to insulin stimulus; positive regulation of tumor necrosis factor production; positive regulation of RNA splicing; phosphatidylinositol biosynthetic process; protein transport; B cell differentiation; viral process; T cell receptor signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; phosphatidylinositol-mediated signaling; leukocyte migration; positive regulation of transcription by RNA polymerase II; signal transduction; phosphatidylinositol 3-kinase signaling; phosphatidylinositol-3-phosphate biosynthetic process; ERBB2 signaling pathway; insulin receptor signaling pathway; axon guidance; regulation of insulin receptor signaling pathway; interleukin-7-mediated signaling pathway; transport; regulation of protein localization to plasma membrane; positive regulation of protein localization to plasma membrane; G protein-coupled receptor signaling pathway; positive regulation of protein kinase B signaling; protein import into nucleus; positive regulation of phosphatidylinositol 3-kinase signaling; cytokine-mediated signaling pathway; positive regulation of protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	5295
	18708
	ENSG00000145675
	ENSMUSG00000041417
	P27986
	P26450
	NM_001242466; NM_181504; NM_181523; NM_181524
	NM_001024955; NM_001077495
	NP_001229395; NP_852556; NP_852664; NP_852665
	NP_001020126; NP_001070963
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.