PIK3R2

PIK3R2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KT1, 2XS6, 3MTT, 3O5Z
Identifiers
Aliases	PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA, phosphoinositide-3-kinase regulatory subunit 2
External IDs	OMIM: 603157; MGI: 1098772; HomoloGene: 3687; GeneCards: PIK3R2; OMA:PIK3R2 - orthologs
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,229,357 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; stromal cell of endometrium; ; prefrontal cortex; ; hippocampus proper; ; superior frontal gyrus; ; left adrenal gland; ; nucleus accumbens; ; temporal lobe; ; Amygdala; ; caudate nucleus;
	Top expressed in
	primary visual cortex; ; striatum of neuraxis; ; superior frontal gyrus; ; hippocampus proper; ; olfactory bulb; ; Cerebellum; ; ganglionic eminence; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol 3-kinase regulator activity; receptor tyrosine kinase binding; 1-phosphatidylinositol-3-kinase regulator activity; protein binding; protein heterodimerization activity; protein phosphatase binding; GTPase activator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotyrosine residue binding; 1-phosphatidylinositol-3-kinase activity;
Cellular component	cytosol; phosphatidylinositol 3-kinase complex; nucleus;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; cellular glucose homeostasis; response to endoplasmic reticulum stress; Fc-epsilon receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; vascular endothelial growth factor receptor signaling pathway; regulation of autophagy; regulation of phosphatidylinositol 3-kinase activity; cellular response to insulin stimulus; protein transport; phosphatidylinositol 3-kinase signaling; T cell receptor signaling pathway; regulation of small GTPase mediated signal transduction; phosphatidylinositol-mediated signaling; leukocyte migration; positive regulation of transcription by RNA polymerase II; signal transduction; insulin receptor signaling pathway; positive regulation of GTPase activity; phosphatidylinositol-3-phosphate biosynthetic process; negative regulation of MAPK cascade; positive regulation of protein kinase B signaling; positive regulation of protein import into nucleus; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	5296
	18709
	n/a
	ENSMUSG00000031834
	O00459
	O08908
	NM_005027
	NM_008841
	NP_005018
	NP_032867
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.

A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.