PIM1

PIM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XQZ, 1XR1, 1XWS, 1YHS, 1YI3, 1YI4, 1YWV, 1YXS, 1YXT, 1YXU, 1YXV, 1YXX, 2BIK, 2BIL, 2BZH, 2BZI, 2BZJ, 2BZK, 2C3I, 2J2I, 2O3P, 2O63, 2O64, 2O65, 2OBJ, 2OI4, 2XIX, 2XIY, 2XIZ, 2XJ0, 2XJ1, 2XJ2, 3A99, 3BGP, 3BGQ, 3BGZ, 3BWF, 3C4E, 3CXW, 3CY2, 3CY3, 3DCV, 3F2A, 3JPV, 3JXW, 3JY0, 3JYA, 3MA3, 3QF9, 3R00, 3R01, 3R02, 3R04, 3T9I, 3UIX, 3UMW, 3UMX, 3VBQ, 3VBT, 3VBV, 3VBW, 3VBX, 3VBY, 3VC4, 3WE8, 4A7C, 4ALU, 4ALV, 4ALW, 4AS0, 4BZN, 4BZO, 4DTK, 4ENX, 4ENY, 4GW8, 4I41, 4IAA, 4JX3, 4JX7, 4K0Y, 4K18, 4K1B, 4LL5, 4LM5, 4MBI, 4MBL, 4MED, 4MTA, 4N6Y, 4N6Z, 4N70, 4RBL, 4RC2, 4RC3, 4RC4, 4RPV, 4TY1, 4WRS, 4WSY, 4WT6, 4XHK, 4XH6, 5C1Q, 5DWR, 5DIA, 5DHJ, 5DGZ, 5EOL, 5IPJ, 5IIS
Identifiers
Aliases	PIM1, PIM, Pim-1 proto-oncogene, serine/threonine kinase
External IDs	OMIM: 164960; MGI: 97584; HomoloGene: 11214; GeneCards: PIM1; OMA:PIM1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	37,175,428 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,715,086 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; granulocyte; ; gastric mucosa; ; gallbladder; ; blood; ; skin of abdomen; ; skin of leg; ; ventricular zone; ; mucosa of pharynx; ; buccal mucosa cell;
	Top expressed in
	granulocyte; ; lip; ; decidua; ; blood; ; morula; ; yolk sac; ; thymus; ; adrenal gland; ; lactiferous gland; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; manganese ion binding; ribosomal small subunit binding; transcription factor binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
Cellular component	cytoplasm; membrane; plasma membrane; nucleoplasm; nucleolus; cytosol; nucleus;
Biological process	phosphorylation; negative regulation of apoptotic process; negative regulation of DNA-binding transcription factor activity; multicellular organism development; protein phosphorylation; hyaluronan metabolic process; protein autophosphorylation; cell cycle; cell population proliferation; vitamin D receptor signaling pathway; apoptotic process; regulation of mitotic cell cycle; positive regulation of cardiac muscle cell proliferation; positive regulation of cardioblast proliferation; cytokine-mediated signaling pathway; positive regulation of transcription, DNA-templated; protein stabilization; regulation of hematopoietic stem cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	5292
	18712
	ENSG00000137193
	ENSMUSG00000024014
	P11309
	P06803
	NM_002648; NM_001243186
	NM_008842; NM_001364913
	NP_001230115; NP_002639
	NP_032868; NP_001351842
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.

Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus. Subsequently, the oncogene has been implicated in multiple human cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies. Primarily expressed in spleen, thymus, bone marrow, prostate, oral epithelial, hippocampus and fetal liver cells, Pim-1 has also been found to be highly expressed in cell cultures isolated from human tumors. Pim-1 is mainly involved in cell cycle progression, apoptosis and transcriptional activation, as well as more general signal transduction pathways. Pim-1's role in oncogenic signalling has led to it becoming a widely studied target in cancer research, with numerous drug candidates under investigation which target it.