PIM2 (gene)

PIM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IWI, 4X7Q
Identifiers
Aliases	PIM2, Pim-2 proto-oncogene, serine/threonine kinase
External IDs	OMIM: 300295; MGI: 97587; HomoloGene: 17098; GeneCards: PIM2; OMA:PIM2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	48,919,024 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,749,671 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; rectum; ; appendix; ; lymph node; ; blood; ; epithelium of colon; ; bone marrow cells; ; mucosa of transverse colon; ; minor salivary glands;
	Top expressed in
	epiblast; ; embryo; ; bone marrow; ; Hypothalamus; ; spleen; ; striatum of neuraxis; ; islet of Langerhans; ; primary visual cortex; ; hippocampus proper; ; Cortex of frontal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
Cellular component	cytoplasm;
Biological process	phosphorylation; male meiotic nuclear division; response to virus; negative regulation of apoptotic process; protein phosphorylation; regulation of mitotic cell cycle; protein autophosphorylation; cell cycle; cell population proliferation; negative regulation of cell population proliferation; apoptotic process; apoptotic mitochondrial changes; positive regulation of autophagy; positive regulation of macroautophagy; negative regulation of protein binding; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of transcription, DNA-templated; protein stabilization; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	11040
	18715
	ENSG00000102096
	ENSMUSG00000031155
	Q9P1W9
	Q62070
	NM_006875
	NM_138606
	NP_006866
	NP_613072
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase Pim-2 is an enzyme that in humans is encoded by the PIM2 (Proviral Integrations of Moloney virus 2) gene. The enzyme is a serine/threonine kinase that has roles in cell growth, proliferation, apoptosis, and regulation of signal transduction cascades.