PINK1

PINK1
Identifiers
Aliases	PINK1, BRPK, PARK6, PTEN induced putative kinase 1, PTEN induced kinase 1
External IDs	OMIM: 608309; MGI: 1916193; HomoloGene: 32672; GeneCards: PINK1; OMA:PINK1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,651,511 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,053,618 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; glutes; ; gastrocnemius muscle; ; right frontal lobe; ; prefrontal cortex; ; Amygdala; ; muscle of thigh; ; apex of heart; ; putamen; ; nucleus accumbens;
	Top expressed in
	muscle of thigh; ; myocardium of ventricle; ; intercostal muscle; ; sciatic nerve; ; digastric muscle; ; triceps brachii muscle; ; ankle; ; sternocleidomastoid muscle; ; temporal muscle; ; extraocular muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C3HC4-type RING finger domain binding; kinase activity; ATP binding; protein kinase activity; metal ion binding; protein serine/threonine kinase activity; calcium-dependent protein kinase activity; peptidase activator activity; magnesium ion binding; transferase activity; protease binding; protein binding; nucleotide binding; protein kinase B binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; cytosol; membrane; mitochondrial intermembrane space; mitochondrion; perinuclear region of cytoplasm; cytoskeleton; nucleus; Lewy body; integral component of mitochondrial outer membrane; mitochondrial outer membrane; chromatin; TORC2 complex; integral component of membrane; ubiquitin ligase complex; mitochondrial outer membrane translocase complex; astrocyte projection; axon; cell body; mitochondrial inner membrane; growth cone;
Biological process	negative regulation of neuron apoptotic process; positive regulation of mitophagy in response to mitochondrial depolarization; positive regulation of free ubiquitin chain polymerization; regulation of protein ubiquitination; cellular response to toxic substance; positive regulation of catecholamine secretion; regulation of synaptic vesicle transport; positive regulation of translation; protein phosphorylation; positive regulation of dopamine secretion; macroautophagy; regulation of protein-containing complex assembly; cellular response to hypoxia; negative regulation of autophagosome assembly; positive regulation of protein kinase B signaling; positive regulation of protein dephosphorylation; ubiquitin-dependent protein catabolic process; peptidyl-serine autophosphorylation; regulation of neuron apoptotic process; response to oxidative stress; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; negative regulation of mitochondrial fission; positive regulation of mitochondrial electron transport, NADH to ubiquinone; positive regulation of macroautophagy; regulation of autophagy of mitochondrion; positive regulation of ubiquitin-protein transferase activity; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; protein ubiquitination; negative regulation of oxidative stress-induced cell death; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; positive regulation of synaptic transmission, dopaminergic; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; regulation of oxidative phosphorylation; regulation of mitochondrion organization; regulation of hydrogen peroxide metabolic process; negative regulation of oxidative stress-induced neuron death; protein stabilization; mitochondrion organization; positive regulation of DNA-binding transcription factor activity; negative regulation of autophagy of mitochondrion; regulation of reactive oxygen species metabolic process; positive regulation of ATP biosynthetic process; maintenance of protein location in mitochondrion; regulation of protein targeting to mitochondrion; positive regulation of release of cytochrome c from mitochondria; respiratory electron transport chain; positive regulation of protein ubiquitination; regulation of proteasomal protein catabolic process; activation of protein kinase B activity; intracellular signal transduction; negative regulation of macroautophagy; positive regulation of protein targeting to mitochondrion; positive regulation of cristae formation; positive regulation of peptidase activity; TORC2 signaling; regulation of mitochondrial membrane potential; autophagy; negative regulation of JNK cascade; establishment of protein localization to mitochondrion; autophagy of mitochondrion; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; cellular response to oxidative stress; negative regulation of reactive oxygen species metabolic process; negative regulation of apoptotic process; positive regulation of protein phosphorylation; positive regulation of histone deacetylase activity; mitochondrion to lysosome transport; regulation of cellular response to oxidative stress; response to ischemia; positive regulation of mitochondrial fission; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; cellular response to hydrogen sulfide; phosphorylation; negative regulation of neuron death; positive regulation of NMDA glutamate receptor activity; negative regulation of intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	65018
	68943
	ENSG00000158828
	ENSMUSG00000028756
	Q9BXM7
	Q99MQ3
	NM_032409
	NM_026880
	NP_115785
	NP_081156
	Wikidata
View/Edit Human	View/Edit Mouse

PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.

It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria. PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.