Prolactin-induced protein

PIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ES6
Identifiers
Aliases	PIP, GCDFP-15, GCDFP15, GPIP4, Prolactin-induced protein, prolactin induced protein, BRST-2
External IDs	OMIM: 176720; MGI: 102696; HomoloGene: 1990; GeneCards: PIP; OMA:PIP - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	143,139,739 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	41,828,999 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; parotid gland; ; olfactory zone of nasal mucosa; ; trachea; ; skin of thigh; ; palpebral conjunctiva; ; skin of arm; ; sperm; ; skin of hip; ; lactiferous duct;
	Top expressed in
	parotid gland; ; lacrimal gland; ; submandibular gland; ; temporal muscle; ; olfactory epithelium; ; masseter muscle; ; sexually immature organism; ; digastric muscle; ; lymph node; ; trachea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; protein dimerization activity; IgG binding; aspartic-type endopeptidase activity;
Cellular component	extracellular region; apical plasma membrane; extracellular exosome; nucleus; extracellular space;
Biological process	negative regulation of T cell apoptotic process; regulation of immune system process; retina homeostasis; positive regulation of gene expression; detection of chemical stimulus involved in sensory perception of bitter taste; transmembrane transport; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	5304
	18716
	ENSG00000159763
	ENSMUSG00000058499
	P12273
	P02816
	NM_002652
	NM_008843
	NP_002643
	NP_032869
	Wikidata
View/Edit Human	View/Edit Mouse

Prolactin-inducible protein also known as gross cystic disease fluid protein 15 (GCDFP-15), extra-parotid glycoprotein (EP-GP), gp17 seminal actin-binding protein (SABP) or BRST2 is a protein that in humans is encoded by the PIP gene. It is upregulated by prolactin and androgens and downregulated by estrogen.