PITX2

PITX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L7F, 2L7M, 2LKX
Identifiers
Aliases	PITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD4
External IDs	OMIM: 601542; MGI: 109340; HomoloGene: 55454; GeneCards: PITX2; OMA:PITX2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	110,642,123 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	129,013,240 bp
RNA expression pattern
	Top expressed in
	gums; ; biceps brachii; ; gingival epithelium; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; gastrocnemius muscle; ; vastus lateralis muscle; ; pituitary gland;
	Top expressed in
	tooth; ; molar; ; umbilical cord; ; subthalamus; ; mesoderm; ; labioscrotal swelling; ; abdominal wall; ; mammillary body; ; lateral plate mesoderm; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; protein homodimerization activity; transcription cis-regulatory region binding; sequence-specific DNA binding; DNA binding; transcription coactivator activity; chromatin DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; ribonucleoprotein complex binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription factor binding; phosphoprotein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytoplasm; transcription regulator complex; nucleoplasm;
Biological process	response to vitamin A; female gonad development; vascular associated smooth muscle cell differentiation; regulation of transcription by RNA polymerase II; skeletal muscle tissue development; cell proliferation involved in outflow tract morphogenesis; prolactin secreting cell differentiation; in utero embryonic development; pituitary gland development; vasculogenesis; regulation of cell population proliferation; myoblast fusion; hair cell differentiation; spleen development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; embryonic camera-type eye development; ventricular septum morphogenesis; endodermal digestive tract morphogenesis; determination of left/right symmetry; cardiac muscle tissue development; positive regulation of transcription, DNA-templated; subthalamic nucleus development; ventricular cardiac muscle cell development; left/right axis specification; hypothalamus cell migration; animal organ morphogenesis; regulation of cell migration; heart development; embryonic digestive tract morphogenesis; branching involved in blood vessel morphogenesis; cardiac muscle cell differentiation; digestive system development; multicellular organism development; atrioventricular valve development; pulmonary vein morphogenesis; cardiac neural crest cell migration involved in outflow tract morphogenesis; embryonic hindlimb morphogenesis; lung development; superior vena cava morphogenesis; positive regulation of DNA binding; extraocular skeletal muscle development; pulmonary myocardium development; deltoid tuberosity development; atrial cardiac muscle tissue morphogenesis; male gonad development; anatomical structure morphogenesis; brain development; neuron differentiation; odontogenesis of dentin-containing tooth; Wnt signaling pathway; left lung morphogenesis; somatotropin secreting cell differentiation; positive regulation of myoblast proliferation; camera-type eye development; response to hormone; odontogenesis; iris morphogenesis; neuron migration; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5308
	18741
	ENSG00000164093
	ENSMUSG00000028023
	Q99697
	P97474
NM_000325; NM_001204397; NM_001204398; NM_001204399; NM_153426;
	NM_153427
	NM_001042502; NM_001042504; NM_001286942; NM_001287048; NM_011098
NP_000316; NP_001191326; NP_001191327; NP_001191328; NP_700475;
	NP_700476
	NP_001035967; NP_001035969; NP_001273871; NP_001273977; NP_035228
	Wikidata
View/Edit Human	View/Edit Mouse

Paired-like homeodomain transcription factor 2 also known as pituitary homeobox 2 is a protein that in humans is encoded by the PITX2 gene.