PKIA

PKIA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CMK, 1JLU, 1Q8T, 1XH4, 1XH5, 1XH6, 1XH7, 1XH8, 1XH9, 1XHA, 1YDR, 2C1A, 2C1B, 2F7E, 2GNI, 2JDS, 2JDT, 2JDV, 2L1L, 2UVY, 2UVZ, 2UW0, 2UW3, 2UW4, 2UW5, 2UW6, 2UW7, 2UW8, 2VNW, 2VNY, 2VO0, 2VO3, 2VO6, 2VO7, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 3WYG, 4AXA, 4IAC, 4IAD, 4IAF, 4IAI, 4IAK, 4IAY, 4IAZ, 4IB0, 4IB1, 4IB3, 4IE9, 4IJ9, 4O21, 4O22, 4WB5, 4WB6, 4WB7, 4WB8, 4Z83, 4Z84, 5DH9, 1Q61, 3X2U, 3X2W, 1Q62, 3X2V, 4UJA, 4UJ9, 4UJB, 4UJ2, 4UJ1
Identifiers
Aliases	PKIA, PRKACN1, protein kinase (cAMP-dependent, catalytic) inhibitor alpha, cAMP-dependent protein kinase inhibitor alpha
External IDs	OMIM: 606059; MGI: 104747; HomoloGene: 7473; GeneCards: PKIA; OMA:PKIA - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	78,605,267 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	7,510,426 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; muscle of thigh; ; thoracic diaphragm; ; deltoid muscle; ; triceps brachii muscle; ; right ventricle; ; myocardium of left ventricle;
	Top expressed in
	barrel cortex; ; intercostal muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; extensor digitorum longus muscle; ; temporal muscle; ; soleus muscle; ; digastric muscle; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding; cAMP-dependent protein kinase inhibitor activity; protein kinase A catalytic subunit binding; kinase activity;
Cellular component	cytoplasm; nucleus;
Biological process	regulation of G2/M transition of mitotic cell cycle; negative regulation of catalytic activity; negative regulation of transcription by RNA polymerase II; negative regulation of cAMP-dependent protein kinase activity; negative regulation of protein kinase activity; negative regulation of protein import into nucleus; negative regulation of protein serine/threonine kinase activity; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5569
	18767
	ENSG00000171033
	ENSMUSG00000027499
	P61925
	P63248
	NM_181839; NM_006823
	NM_008862
	NP_006814; NP_862822; NP_006814.1; NP_862822.1
	NP_032888
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-dependent protein kinase inhibitor alpha is a protein that in humans is encoded by the PKIA gene.

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.