PKIB

PKIB
Identifiers
Aliases	PKIB, PRKACN2, protein kinase (cAMP-dependent, catalytic) inhibitor beta, cAMP-dependent protein kinase inhibitor beta
External IDs	OMIM: 606914; MGI: 101937; HomoloGene: 7474; GeneCards: PKIB; OMA:PKIB - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	122,726,373 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	57,617,208 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; mucosa of ileum; ; mucosa of transverse colon; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; rectum; ; mucosa of sigmoid colon; ; placenta; ; bronchial epithelial cell; ; Pons;
	Top expressed in
	seminiferous tubule; ; spermatid; ; olfactory epithelium; ; lumbar spinal ganglion; ; lobe of cerebellum; ; cerebellar vermis; ; suprachiasmatic nucleus; ; supraoptic nucleus; ; carotid body; ; pontine nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase inhibitor activity; cAMP-dependent protein kinase inhibitor activity;
Cellular component	cytoplasm; nucleus;
Biological process	positive regulation of telomere maintenance via telomerase; positive regulation of telomere capping; positive regulation of telomerase activity; negative regulation of cAMP-dependent protein kinase activity; negative regulation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5570
	18768
	ENSG00000135549
	ENSMUSG00000019876
	Q9C010
	Q04758
NM_001270393; NM_001270394; NM_001270395; NM_032471; NM_181794;
	NM_181795
NM_001039050; NM_001039051; NM_001039052; NM_001039053; NM_001190402;
	NM_008863
NP_001257322; NP_001257323; NP_001257324; NP_115860; NP_861459;
	NP_861460
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-dependent protein kinase inhibitor beta is a protein that in humans is encoded by the PKIB gene.

The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported.