PKIG

PKIG
Identifiers
Aliases	PKIG, PKI-gamma, protein kinase (cAMP-dependent, catalytic) inhibitor gamma, cAMP-dependent protein kinase inhibitor gamma
External IDs	OMIM: 604932; MGI: 1343086; HomoloGene: 5133; GeneCards: PKIG; OMA:PKIG - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	44,624,247 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,568,078 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; right ventricle; ; apex of heart; ; left coronary artery; ; right auricle of heart; ; left ventricle; ; myocardium; ; vena cava; ; gastric mucosa; ; cardiac muscle tissue of right atrium;
	Top expressed in
	otic placode; ; saccule; ; aortic valve; ; endocardial cushion; ; atrioventricular valve; ; ascending aorta; ; renal corpuscle; ; otic vesicle; ; Paneth cell; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; cAMP-dependent protein kinase inhibitor activity;
Cellular component	cytoplasm; nucleus;
Biological process	negative regulation of transcription by RNA polymerase II; negative regulation of cAMP-dependent protein kinase activity; signal transduction; negative regulation of protein kinase activity; negative regulation of protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	11142
	18769
	ENSG00000168734
	ENSMUSG00000035268
	Q9Y2B9
	O70139
	NM_181805; NM_001281444; NM_001281445; NM_007066; NM_181804
NM_001039390; NM_001039391; NM_001164053; NM_001164055; NM_001277096;
	NM_011106
	NP_001268373; NP_001268374; NP_008997; NP_861520; NP_861521
NP_001034479; NP_001034480; NP_001157525; NP_001157527; NP_001264025;
	NP_035236
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene.

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.