PKMYT1

PKMYT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3P1A
Identifiers
Aliases	PKMYT1, MYT1, PPP1R126, protein kinase, membrane associated tyrosine/threonine 1
External IDs	OMIM: 602474; MGI: 2137630; HomoloGene: 31227; GeneCards: PKMYT1; OMA:PKMYT1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,980,479 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	23,955,709 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; ventricular zone; ; ganglionic eminence; ; mucosa of transverse colon; ; gonad; ; oocyte; ; secondary oocyte; ; prefrontal cortex; ; right hemisphere of cerebellum;
	Top expressed in
	spermatocyte; ; motor neuron; ; seminiferous tubule; ; zygote; ; secondary oocyte; ; fetal liver hematopoietic progenitor cell; ; primary oocyte; ; epithelium of small intestine; ; mucous cell of stomach; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; protein serine/threonine kinase activity; protein binding; ATP binding; kinase activity;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; Golgi membrane; nucleoplasm; endoplasmic reticulum; nucleus; nucleolus; Golgi apparatus;
Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity; phosphorylation; negative regulation of phosphatase activity; regulation of cell cycle; protein phosphorylation; G2/M transition of mitotic cell cycle; cell cycle; regulation of mitotic nuclear division; mitotic cell cycle; meiosis;
	Sources:Amigo / QuickGO
Orthologs
	9088
	268930
	ENSG00000127564
	ENSMUSG00000023908
	Q99640; Q0IJ49
	Q9ESG9
	NM_001258450; NM_001258451; NM_004203; NM_182687
	NM_023058
	NP_001245379; NP_001245380; NP_004194; NP_872629; NP_004194.3
	NP_075545
	Wikidata
View/Edit Human	View/Edit Mouse

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase also known as Myt1 kinase is an enzyme that in humans is encoded by the PKMYT1 gene.

Myt 1 is an enzyme in the Wee1 family and found in vertebrates. The Wee 1 family includes a variety of enzymes that all work to inhibit Cdk activity in a variety of different organisms. Myt 1 is important in regulating the cell cycle through inactivating Cdks through the phosphorylation of both Tyr 15 and Thr 14