Protein kinase N1

PKN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CXZ, 1URF, 2RMK, 4NKG, 4OTD, 4OTG, 4OTH, 4OTI
Identifiers
Aliases	PKN1, DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1, Protein kinase N1
External IDs	OMIM: 601032; MGI: 108022; HomoloGene: 48130; GeneCards: PKN1; OMA:PKN1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,471,867 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,425,808 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; granulocyte; ; ventricular zone; ; right lung; ; stromal cell of endometrium; ; muscle of thigh; ; ganglionic eminence; ; monocyte; ; upper lobe of left lung; ; gastric mucosa;
	Top expressed in
	granulocyte; ; thymus; ; muscle of thigh; ; superior frontal gyrus; ; external carotid artery; ; ventricular zone; ; right ventricle; ; primary visual cortex; ; right kidney; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein kinase C activity; histone binding; histone deacetylase binding; chromatin binding; histone kinase activity (H3-T11 specific); kinase activity; protein serine/threonine kinase activity; protein binding; androgen receptor binding; nuclear receptor coactivator activity; ATP binding; protein kinase C binding;
Cellular component	cytoplasm; cytosol; endosome; membrane; plasma membrane; nucleoplasm; midbody; cleavage furrow; nucleus; cytoplasmic vesicle; protein-containing complex;
Biological process	regulation of germinal center formation; negative regulation of protein phosphorylation; renal system process; regulation of transcription, DNA-templated; B cell apoptotic process; negative regulation of protein kinase activity; phosphorylation; regulation of transcription by RNA polymerase II; B cell homeostasis; spleen development; hyperosmotic response; transcription, DNA-templated; regulation of cell motility; protein phosphorylation; peptidyl-serine phosphorylation; epithelial cell migration; negative regulation of B cell proliferation; regulation of immunoglobulin production; signal transduction; chromatin organization; positive regulation of nucleic acid-templated transcription; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5585
	320795
	ENSG00000123143
	ENSMUSG00000057672
	Q16512
	P70268
	NM_002741; NM_213560
	NM_001199593; NM_177262
	NP_002732; NP_998725
	NP_001186522; NP_796236
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene.