PKNOX2

PKNOX2
Identifiers
Aliases	PKNOX2, PREP2, PBX/knotted 1 homeobox 2
External IDs	OMIM: 613066; MGI: 2445415; HomoloGene: 32527; GeneCards: PKNOX2; OMA:PKNOX2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	125,433,389 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	37,058,703 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; sural nerve; ; right frontal lobe; ; primary visual cortex; ; prefrontal cortex; ; cartilage tissue; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; Brodmann area 23; ; superior frontal gyrus;
	Top expressed in
	muscle of thigh; ; tail of embryo; ; gastrula; ; Gonadal ridge; ; dentate gyrus of hippocampal formation granule cell; ; piriform cortex; ; superior frontal gyrus; ; lumbar spinal ganglion; ; skeletal muscle tissue; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; actin filament binding; actin monomer binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; microtubule cytoskeleton; actin cytoskeleton; nucleus; nucleoplasm; intercellular bridge;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	63876
	208076
	ENSG00000165495
	ENSMUSG00000035934
	Q96KN3
	Q8BG99
	NM_022062
	NM_001029838; NM_148950
NP_001369252; NP_001369253; NP_001369254; NP_001369255; NP_001369256;
	NP_001369257; NP_001369258; NP_001369259; NP_001369260; NP_001369261; NP_001369262; NP_001369263; NP_001369264; NP_001369265; NP_001369266; NP_001369267; NP_001369268; NP_001369269; NP_001369270
	NP_001025009; NP_683752
	Wikidata
View/Edit Human	View/Edit Mouse

PBX/Knotted 1 Homeobox 2 (PKNOX2) protein belongs to the three amino acid loop extension (TALE) class of homeodomain proteins, and is encoded by PKNOX2 gene in humans. The protein regulates the transcription of other genes and affects anatomical development.