Lipoprotein-associated phospholipase A2

PLA2G7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D59, 3D5E, 3F96, 3F97, 3F98, 3F9C, 5JAU, 5JAR, 5I9I, 5JAD, 5JAO, 5I8P, 5JAS, 5JAN, 5JAL, 5JAH, 5JAP, 5JAT
Identifiers
Aliases	PLA2G7, LDL-PLA2, LP-PLA2, PAFAD, PAFAH, Lipoprotein-associated phospholipase A2, phospholipase A2 group VII
External IDs	OMIM: 601690; MGI: 1351327; HomoloGene: 3725; GeneCards: PLA2G7; OMA:PLA2G7 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	46,735,693 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,923,092 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; decidua; ; appendix; ; monocyte; ; lymph node; ; spleen; ; mucosa of sigmoid colon; ; rectum; ; endometrium; ; palpebral conjunctiva;
	Top expressed in
	stroma of bone marrow; ; deep cerebellar nuclei; ; medial vestibular nucleus; ; lobe of cerebellum; ; cerebellar vermis; ; dorsal tegmental nucleus; ; stria vascularis; ; pontine nuclei; ; vestibular sensory epithelium; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium-independent phospholipase A2 activity; hydrolase activity; phospholipid binding; hydrolase activity, acting on ester bonds; 1-alkyl-2-acetylglycerophosphocholine esterase activity;
Cellular component	cytoplasm; extracellular region; low-density lipoprotein particle; extracellular space;
Biological process	lipid catabolic process; lipid oxidation; plasma lipoprotein particle oxidation; positive regulation of monocyte chemotaxis; positive regulation of inflammatory response; low-density lipoprotein particle remodeling; lipid metabolism; platelet activating factor metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	7941
	27226
	ENSG00000146070
	ENSMUSG00000023913
	Q13093
	Q60963
	NM_001168357; NM_005084
	NM_013737
	NP_001161829; NP_005075
	NP_038765
	Wikidata
View/Edit Human	View/Edit Mouse

Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A₂ enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA₂ is a 45-kDa protein of 441 amino acids. It is one of several PAF acetylhydrolases.