PLAGL2

PLAGL2
Identifiers
Aliases	PLAGL2, ZNF900, PLAG1 like zinc finger 2
External IDs	OMIM: 604866; MGI: 1933165; HomoloGene: 1994; GeneCards: PLAGL2; OMA:PLAGL2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	32,207,743 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	153,083,346 bp
RNA expression pattern
	Top expressed in
	sperm; ; monocyte; ; secondary oocyte; ; granulocyte; ; testicle; ; gonad; ; amniotic fluid; ; buccal mucosa cell; ; right testis; ; left testis;
	Top expressed in
	epithelium of small intestine; ; tail of embryo; ; genital tubercle; ; fetal liver hematopoietic progenitor cell; ; migratory enteric neural crest cell; ; lens; ; maxillary prominence; ; mandibular prominence; ; ileum; ; inner renal medulla;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; DNA binding; nucleic acid binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; chylomicron assembly; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; lipid metabolism; positive regulation of intrinsic apoptotic signaling pathway; post-embryonic development; transcription by RNA polymerase II; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5326
	54711
	ENSG00000126003
	ENSMUSG00000051413
	Q9UPG8
	Q925T4
	NM_002657
	NM_018807
	NP_002648
	NP_061277
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene.

Zinc finger protein PLAGL2 is a zinc finger protein that recognizes DNA and/or RNA.

The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors.