PLCB3

PLCB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OHM, 4GNK, 4QJ3, 4QJ4, 4QJ5
Identifiers
Aliases	PLCB3, phospholipase C beta 3, SMDCD
External IDs	OMIM: 600230; MGI: 104778; HomoloGene: 47960; GeneCards: PLCB3; OMA:PLCB3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,269,150 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,953,838 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; tendon of biceps brachii; ; duodenum; ; buccal mucosa cell; ; right adrenal gland; ; ectocervix; ; left adrenal cortex; ; stromal cell of endometrium; ; right adrenal cortex; ; right coronary artery;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; duodenum; ; jejunum; ; lumbar spinal ganglion; ; ileum; ; lip; ; left colon; ; cumulus cell; ; migratory enteric neural crest cell; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; signal transducer activity; phosphoric diester hydrolase activity; hydrolase activity; phosphatidylinositol phospholipase C activity; cadherin binding; protein binding; calmodulin binding; phospholipase C activity;
Cellular component	cytosol; membrane; nucleoplasm; protein-containing complex; postsynaptic cytosol;
Biological process	intracellular signal transduction; lipid metabolism; inositol phosphate metabolic process; lipid catabolic process; regulation of systemic arterial blood pressure; signal transduction; Wnt signaling pathway, calcium modulating pathway; G protein-coupled receptor signaling pathway; inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	5331
	18797
	ENSG00000149782
	ENSMUSG00000024960
	Q01970
	P51432
	NM_000932; NM_001184883; NM_001316314
	NM_001290349; NM_008874
	NP_000923; NP_001171812; NP_001303243
	NP_001277278; NP_032900
	Wikidata
View/Edit Human	View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.

The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This enzyme is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.