PLCE1

PLCE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BYE, 2BYF, 2C5L
Identifiers
Aliases	PLCE1, NPHS3, PLCE, PPLC, phospholipase C epsilon 1
External IDs	OMIM: 608414; MGI: 1921305; HomoloGene: 9478; GeneCards: PLCE1; OMA:PLCE1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	94,332,823 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	38,773,474 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; ventricular zone; ; retinal pigment epithelium; ; mucosa of colon; ; ganglionic eminence; ; mucosa of sigmoid colon; ; tibial arteries; ; islet of Langerhans; ; parotid gland;
	Top expressed in
	retinal pigment epithelium; ; vestibular membrane of cochlear duct; ; transitional epithelium of urinary bladder; ; primary oocyte; ; sciatic nerve; ; trigeminal ganglion; ; stria vascularis; ; Epithelium of choroid plexus; ; vestibular sensory epithelium; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; signal transducer activity; protein binding; phosphoric diester hydrolase activity; enzyme binding; phospholipase C activity; hydrolase activity; phosphatidylinositol phospholipase C activity; metal ion binding;
Cellular component	cytosol; Golgi apparatus; membrane; Golgi membrane; plasma membrane; cytoplasm;
Biological process	intracellular signal transduction; epidermal growth factor receptor signaling pathway; regulation of G protein-coupled receptor signaling pathway; regulation of smooth muscle contraction; lipid metabolism; positive regulation of cytosolic calcium ion concentration; small GTPase mediated signal transduction; regulation of Ras protein signal transduction; glomerulus development; inositol phosphate metabolic process; diacylglycerol biosynthetic process; lipid catabolic process; phospholipase C-activating G protein-coupled receptor signaling pathway; heart development; cytoskeleton organization; regulation of cell growth; regulation of protein kinase activity; cell population proliferation; inositol phosphate-mediated signaling; calcium-mediated signaling; signal transduction; Ras protein signal transduction; inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	51196
	74055
	ENSG00000138193
	ENSMUSG00000024998
	Q9P212
	Q8K4S1
	NM_001165979; NM_001288989; NM_016341
	NM_019588
	NP_001159451; NP_001275918; NP_057425
	NP_062534
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase enzyme (PLCE1) that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). Mutations in this gene cause early-onset nephrotic syndrome and have been associated with respiratory chain deficiency with diffuse mesangial sclerosis.