PLCG1

PLCG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HSQ, 2HSP, 4EY0, 4FBN
Identifiers
Aliases	PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, phospholipase C gamma 1
External IDs	OMIM: 172420; MGI: 97615; HomoloGene: 1997; GeneCards: PLCG1; OMA:PLCG1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	41,196,801 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	160,617,680 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right lobe of thyroid gland; ; ganglionic eminence; ; left lobe of thyroid gland; ; right ovary; ; ventricular zone; ; canal of the cervix; ; body of uterus; ; left ovary; ; stromal cell of endometrium;
	Top expressed in
	otolith organ; ; hand; ; utricle; ; aortic valve; ; ascending aorta; ; Rostral migratory stream; ; fossa; ; cumulus cell; ; internal carotid artery; ; condyle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; neurotrophin TRKA receptor binding; receptor tyrosine kinase binding; signal transducer activity; metal ion binding; protein binding; phosphoric diester hydrolase activity; phospholipase C activity; glutamate receptor binding; hydrolase activity; protein kinase binding; phosphatidylinositol phospholipase C activity;
Cellular component	cytoplasm; cytosol; cell projection; cell-cell junction; ruffle; plasma membrane; COP9 signalosome; lamellipodium; Schaffer collateral - CA1 synapse; glutamatergic synapse; intracellular anatomical structure;
Biological process	intracellular signal transduction; Fc-gamma receptor signaling pathway involved in phagocytosis; lipid metabolism; positive regulation of epithelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; in utero embryonic development; inositol phosphate metabolic process; positive regulation of angiogenesis; cellular response to epidermal growth factor stimulus; Fc-epsilon receptor signaling pathway; lipid catabolic process; positive regulation of blood vessel endothelial cell migration; phospholipid catabolic process; viral process; T cell receptor signaling pathway; cell migration; leukocyte migration; calcium-mediated signaling; epidermal growth factor receptor signaling pathway; axon guidance; positive regulation of vascular endothelial cell proliferation; positive regulation of endothelial cell apoptotic process; signal transduction; activation of phospholipase C activity; positive regulation of phospholipase C activity; modulation of chemical synaptic transmission; calcium ion transport; inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	5335
	18803
	ENSG00000124181
	ENSMUSG00000016933
	P19174
	Q62077
	NM_002660; NM_182811
	NM_021280
	NP_002651; NP_877963
	NP_067255
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase C, gamma 1, also known as PLCG1 and PLCgamma1, is a protein that in humans involved in cell growth, migration, apoptosis, and proliferation. It is encoded by the PLCG1 gene and is part of the PLC superfamily.