Perilipin-5

PLIN5
Identifiers
Aliases	PLIN5, LSDA5, LSDP5, MLDP, OXPAT, perilipin 5
External IDs	OMIM: 613248; MGI: 1914218; HomoloGene: 41654; GeneCards: PLIN5; OMA:PLIN5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,535,224 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,424,596 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; apex of heart; ; body of pancreas; ; gastrocnemius muscle; ; left ovary; ; right ovary; ; muscle of thigh; ; tibialis anterior muscle; ; body of stomach; ; left ventricle;
	Top expressed in
	interventricular septum; ; intercostal muscle; ; myocardium of ventricle; ; left lobe of liver; ; soleus muscle; ; thoracic diaphragm; ; digastric muscle; ; right ventricle; ; brown adipose tissue; ; cardiac muscles;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipase binding; identical protein binding;
Cellular component	cytosol; cytoplasm; lipid droplet; mitochondrion;
Biological process	lipid storage; negative regulation of lipid catabolic process; mitochondrion localization; positive regulation of fatty acid beta-oxidation; lipid droplet organization; negative regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of triglyceride biosynthetic process; positive regulation of lipase activity; positive regulation of lipid storage; negative regulation of triglyceride catabolic process; negative regulation of lipase activity; negative regulation of reactive oxygen species metabolic process; positive regulation of sequestering of triglyceride; negative regulation of fatty acid beta-oxidation;
	Sources:Amigo / QuickGO
Orthologs
	440503
	66968
	ENSG00000214456
	ENSMUSG00000011305
	Q00G26
	Q8BVZ1
	NM_001013706
	NM_001077348; NM_025874
	NP_001013728
	NP_001070816; NP_080150
	Wikidata
View/Edit Human	View/Edit Mouse

Perilipin 5, also known as Oxpatperilipin 5 or PLIN5, is a protein that belongs to perilipin family. This protein group has been shown to be responsible for lipid droplet's biogenesis, structure and degradation. In particular, Perilipin 5 is a lipid droplet-associated protein whose function is to keep the balance between lipolysis and lipogenesis, as well as maintaining lipid droplet homeostasis. For example, in oxidative tissues, muscular tissues and cardiac tissues, PLIN5 promotes association between lipid droplets and mitochondria.

Inside the cell, PLIN5 can be found in multiple intracellular structures including lipid droplets, endoplasmic reticulum, mitochondria, and the cytosol. The wrong expression of this protein has been proven to be related with diseases such as skeletal muscle diseases, liver diseases or carcinogenesis.