PLK1

PLK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q4K, 1Q4O, 1UMW, 2OJX, 2OU7, 2OWB, 2RKU, 2V5Q, 2YAC, 3BZI, 3C5L, 3FVH, 3HIH, 3HIK, 3KB7, 3P2W, 3P2Z, 3P34, 3P35, 3P36, 3P37, 3Q1I, 3RQ7, 3THB, 4A4L, 4A4O, 4DFW, 4E67, 4E9C, 4E9D, 4H5X, 4H71, 4HAB, 4HCO, 4HY2, 4J52, 4J53, 4LKL, 4LKM, 4O56, 4O6W, 4O9W, 4RCP, 4WHH, 4WHL, 4X9R, 4X9V, 4X9W, 2OGQ, 5J19
Identifiers
Aliases	PLK1, PLK, STPK13, polo like kinase 1
External IDs	OMIM: 602098; MGI: 97621; HomoloGene: 3690; GeneCards: PLK1; OMA:PLK1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	23,690,367 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	121,769,096 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gonad; ; ganglionic eminence; ; mucosa of transverse colon; ; left testis; ; right testis; ; stromal cell of endometrium; ; rectum; ; testicle; ; secondary oocyte;
	Top expressed in
	tail of embryo; ; epiblast; ; otic vesicle; ; zygote; ; otic placode; ; spermatid; ; yolk sac; ; secondary oocyte; ; abdominal wall; ; primitive streak;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; microtubule binding; kinase activity; protein binding; anaphase-promoting complex binding; protein kinase binding; protein serine/threonine kinase activity; magnesium ion binding; protein kinase activity; ATP binding; identical protein binding;
Cellular component	cytosol; centrosome; spindle pole; microtubule cytoskeleton; spindle; nucleoplasm; chromosome; microtubule organizing center; midbody; spindle microtubule; spindle midzone; chromatin; synaptonemal complex; chromosome, centromeric region; cytoskeleton; nucleus; kinetochore; cytoplasm; centriole; centriolar satellite;
Biological process	phosphorylation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; establishment of protein localization; synaptonemal complex disassembly; mitotic cytokinesis; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; homologous chromosome segregation; regulation of mitotic spindle assembly; mitotic spindle assembly checkpoint signaling; regulation of cell cycle; cell division; mitotic nuclear membrane disassembly; G2/M transition of mitotic cell cycle; positive regulation of peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; microtubule bundle formation; protein ubiquitination; protein destabilization; regulation of mitotic cell cycle; positive regulation of ubiquitin-protein transferase activity; positive regulation of proteolysis; mitotic sister chromatid segregation; regulation of mitotic metaphase/anaphase transition; cell cycle; anaphase-promoting complex-dependent catabolic process; cell population proliferation; regulation of protein binding; protein localization to chromatin; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; female meiosis chromosome segregation; positive regulation of protein localization to nucleus; sister chromatid cohesion; regulation of cell cycle G2/M phase transition; mitotic cell cycle; protein phosphorylation; centrosome cycle; nuclear membrane disassembly; protein localization to nuclear envelope; ciliary basal body-plasma membrane docking; positive regulation of ubiquitin protein ligase activity; regulation of G2/M transition of mitotic cell cycle; regulation of cytokinesis; mitotic G2 DNA damage checkpoint signaling; protein localization to organelle; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process; establishment of mitotic spindle orientation; regulation of protein localization to cell cortex;
	Sources:Amigo / QuickGO
Orthologs
	5347
	18817
	ENSG00000166851
	ENSMUSG00000030867
	P53350
	Q07832
	NM_005030
	NM_011121
	NP_005021
	NP_035251
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene.